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Drug Interactions between mirabegron and solifenacin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

solifenacin mirabegron

Applies to: solifenacin and mirabegron

MONITOR: Urinary retention has been reported during postmarketing use of mirabegron in patients receiving antimuscarinic medications for the treatment of overactive bladder.

MANAGEMENT: Caution is advised if mirabegron is prescribed in combination with antimuscarinic medications used for the treatment of overactive bladder.

References

  1. (2012) "Product Information. Myrbetriq (mirabegron)." Astellas Pharma US, Inc

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Drug and food interactions

Minor

mirabegron food

Applies to: mirabegron

Food reduces the oral absorption and bioavailability of mirabegron. According to the product labeling, administration of a 50 mg tablet with a high-fat meal decreased mirabegron peak plasma concentration (Cmax) and systemic exposure (AUC) by 45% and 17%, respectively, whereas administration with a low-fat meal decreased mirabegron Cmax and AUC by 75% and 51%, respectively. In phase 3 clinical studies demonstrating both safety and efficacy, mirabegron was administered without regards to food content and intake. Therefore, mirabegron can be taken with or without food at the recommended dosage.

References

  1. (2012) "Product Information. Myrbetriq (mirabegron)." Astellas Pharma US, Inc

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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