Drug Interactions between mifepristone and ulipristal
This report displays the potential drug interactions for the following 2 drugs:
- mifepristone
- ulipristal
Interactions between your drugs
No interactions were found between mifepristone and ulipristal. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
mifepristone
A total of 628 drugs are known to interact with mifepristone.
- Mifepristone is in the following drug classes: progesterone receptor modulators, uterotonic agents.
- Mifepristone is used to treat the following conditions:
ulipristal
A total of 210 drugs are known to interact with ulipristal.
- Ulipristal is in the drug class progesterone receptor modulators.
-
Ulipristal is used to treat the following conditions:
- Birth Control (off-label)
- Emergency Contraception
- Uterine Fibroids (off-label)
Drug and food interactions
miFEPRIStone food
Applies to: mifepristone
ADJUST DOSING INTERVAL: Food may significantly increase the plasma concentrations of mifepristone.
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of mifepristone. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Because pharmacokinetic interactions involving grapefruit juice are often subject to a high degree of interpatient variability, the extent to which a given patient may be affected is difficult to predict.
MANAGEMENT: When mifepristone is used daily to control hyperglycemia secondary to hypercortisolism in patients with endogenous Cushing's syndrome, it should be taken with food to achieve consistent plasma drug levels. Patients should be advised to avoid consuming grapefruit or grapefruit juice during treatment with mifepristone, as it may cause increased adverse effects such as headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, hypokalemia, adrenal insufficiency, vaginal bleeding, arthralgia, peripheral edema, and hypertension. Because mifepristone is eliminated slowly from the body, the interaction with grapefruit juice may be observed for a prolonged period.
References
- (2001) "Product Information. Mifeprex (mifepristone)." Danco Laboratories
- (2012) "Product Information. Korlym (mifepristone)." Corcept Therapeutics Incorporated
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Progesterone receptor modulators
Therapeutic duplication
The recommended maximum number of medicines in the 'progesterone receptor modulators' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'progesterone receptor modulators' category:
- mifepristone
- ulipristal
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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