Drug interactions between midazolam and posaconazole
Interactions between your drugs
midazolam ↔ posaconazole
Applies to:midazolam and posaconazole
Using midazolam together with posaconazole can increase the effects of midazolam. This can cause extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, or coma. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
Applies to: midazolam
Grapefruit and grapefruit juice may interact with midazolam and lead to potentially dangerous side effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Do not drink alcohol while taking midazolam. This medication can increase the effects of alcohol. You may feel more drowsy, dizzy, or tired if you take midazolam with alcohol. Talk to your doctor or pharmacist if you have any questions or concerns.
Applies to: posaconazole
Food significantly increases the absorption of posaconazole from the tablet or suspension formulations. The manufacturer recommends that you take the tablet with food and the oral suspension during or immediately (within 20 minutes) after a full meal. If you cannot eat a full meal, you should take the oral suspension with a liquid nutritional supplement like Ensure or an acidic carbonated beverage like ginger ale. Do not take these medications on an empty stomach, as it may lead to inadequate blood levels and reduced effectiveness. Talk to your doctor or pharmacist if you have any questions on how to use the medication properly.
Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.