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Drug Interactions between metyrosine and pentoxifylline

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

pentoxifylline metyroSINE

Applies to: pentoxifylline and metyrosine

MONITOR: Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with pentoxifylline plus nifedipine or captopril. The mechanism of interaction has not been described.

MANAGEMENT: Caution is advised if pentoxifylline is used in combination with hypotensive agents. Periodic systemic blood pressure monitoring is recommended.

References (1)
  1. (2001) "Product Information. Trental (pentoxifylline)." Hoechst Marion Roussel

Drug and food interactions

Moderate

metyroSINE food

Applies to: metyrosine

MONITOR: Metyrosine, when coadministered with other CNS depressants including alcoholic beverages, may lead to excessive somnolence and other forms of nervous system depression.

MANAGEMENT: The patient should be informed to use caution if these agents are coadministered, especially if performing hazardous tasks such as driving or operating machinery.

References (1)
  1. (2001) "Product Information. Demser (metyrosine)." Merck & Co., Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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