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Drug Interactions between methylprednisolone and tacrolimus

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

methylPREDNISolone tacrolimus

Applies to: methylprednisolone and tacrolimus

Consumer information for this interaction is not currently available.

MONITOR: Corticosteroids may decrease tacrolimus concentrations. The mechanism of interaction has not been established but may involve induction of CYP450 3A4/5 by corticosteroids. In a prospective, observational study of kidney transplant patients (n=2462), steroids were associated with increased clearance of tacrolimus by 3% to 11.8%. Patients were categorized by the number of loss of function alleles (LOF) (CYP450 3A4*22, 3A5*3, *6, and *7), and tacrolimus clearance increased by 11.8% in patients with zero LOF (0-LOF), 5% in 1-LOF, 3% in 2-LOF, and 10.3% in 3/4-LOF. Risk of organ rejection may be increased.

MANAGEMENT: Increased monitoring of tacrolimus whole blood trough concentrations and graft function may be advisable, especially during initiation and discontinuation of corticosteroid treatment, and the tacrolimus dose adjusted as needed.

Drug and food/lifestyle interactions

Major

tacrolimus food/lifestyle

Applies to: tacrolimus

Tacrolimus should be taken on a consistent schedule before or after you eat at the same times each day. Grapefruit and grapefruit juice may increase the amount of tacrolimus in your body. This can lead to potentially dangerous side effects and should be avoided. If you are already consuming grapefruit products, do not increase or decrease the amount of these products in your diet without first talking to your doctor.

Moderate

methylPREDNISolone food/lifestyle

Applies to: methylprednisolone

Grapefruit juice may increase the blood levels of certain medications such as methylPREDNISolone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with methylPREDNISolone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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