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Drug Interactions between methotrimeprazine and Sofdra

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

methotrimeprazine sofpironium topical

Applies to: methotrimeprazine and Sofdra (sofpironium topical)

GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 2D6 may significantly increase the plasma concentrations of topical sofpironium, which has been shown to be partially metabolized by the isoenzyme. In a pharmacokinetic study in patients with primary axillary hyperhidrosis, sofpironium systemic exposure (AUC) and peak plasma concentration (Cmax) increased approximately 2 -fold following concomitant use with the potent CYP450 2D6 inhibitor paroxetine at a 20 mg oral dose.

MANAGEMENT: Coadministration of topical sofpironium with potent CYP450 2D6 inhibitors should generally be avoided. If coadministration is required, monitor for sofpironium-related adverse effects which include blurred vision, urinary retention, difficulty controlling body temperature in warm environments, and dry mouth.

References (1)
  1. (2024) "Product Information. Sofdra (sofpironium topical)." Botanix SB Inc.,

Drug and food interactions

Moderate

methotrimeprazine food

Applies to: methotrimeprazine

GENERALLY AVOID: Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment. Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines. The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.

MANAGEMENT: Patients should be advised to avoid alcohol during phenothiazine therapy.

References (2)
  1. Lutz EG (1976) "Neuroleptic-induced akathisia and dystonia triggered by alcohol." JAMA, 236, p. 2422-3
  2. Freed E (1981) "Alcohol-triggered-neuroleptic-induced tremor, rigidity and dystonia." Med J Aust, 2, p. 44-5

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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