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Drug interactions between Malarone and Vivotif Berna Vaccine

Results for the following 2 drugs:
Malarone (atovaquone/proguanil)
Vivotif Berna Vaccine (typhoid vaccine, live)

Interactions between your drugs

Moderate

atovaquone ↔ typhoid vaccine, live

Applies to:Malarone (atovaquone/proguanil) and Vivotif Berna Vaccine (typhoid vaccine, live)

If you are currently being treated with atovaquone or have been treated within the last 3 days, you should talk to your doctor before receiving typhoid vaccine, live. Antibiotics like atovaquone can reduce the activity of the vaccine. To ensure adequate vaccine response, you should not receive typhoid vaccine, live until at least 3 days after you complete your atovaquone therapy. If you have just been vaccinated, it would be best to wait at least 3 days before using atovaquone. Your doctor may be able to prescribe a different antibiotic if you need treatment for an infection. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

typhoid vaccine, live ↔ proguanil

Applies to:Vivotif Berna Vaccine (typhoid vaccine, live) and Malarone (atovaquone/proguanil)

Ask your doctor before using typhoid vaccine, live together with proguanil. Proguanil can decrease the effectiveness of typhoid vaccine, live. Medications containing proguanil should not be administered until at least 10 days after the last dose of typhoid vaccine, live. This vaccine works by exposing you to a small dose of the virus or a protein from the virus, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

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Drug and food interactions

Moderate

atovaquone food

Applies to: Malarone (atovaquone / proguanil)

Food significantly enhances the absorption of atovaquone. You should take each dose of atovaquone at the same time each day with a meal or a milky drink. If you receive enteral nutrition (tube feeding), take atovaquone with your feeding. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Talk to your doctor if you have questions or have difficulty taking atovaquone with food.

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Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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