Drug Interactions between magnesium sulfate / potassium chloride / sodium sulfate and streptomycin
This report displays the potential drug interactions for the following 2 drugs:
- magnesium sulfate/potassium chloride/sodium sulfate
- streptomycin
Interactions between your drugs
streptomycin magnesium sulfate
Applies to: streptomycin and magnesium sulfate / potassium chloride / sodium sulfate
MONITOR CLOSELY: Aminoglycosides possess neuromuscular blocking activity, which may be additive with that of parenteral magnesium, potentially resulting in severe and/or prolonged respiratory depression during concomitant use. Clinical data are limited; however, this interaction has been reported in animal studies. In addition, aminoglycosides may reduce serum magnesium levels.
MANAGEMENT: Close monitoring for increased or prolonged neuromuscular blockade and respiratory depression is recommended during concomitant use, especially in patients with renal impairment and/or with elevated magnesium levels. It may be advisable to avoid administration of aminoglycosides in infants with hypermagnesemia.
References
- Watson A, Coffey L, Keogh B, McCann SR (1983) "Severe hypomagnesaemia and hypocalcaemia following gentamicin therapy." Isr J Med Sci, 76, p. 381-3
- L'Hommedieu CS, Nicholas D, Armes DA, et al. (1983) "Potentiation of magnesium sulfate-induced neuromuscular weakness by gentamicin, tobramycin, and amikacin." J Pediatr, 102, p. 629-31
- Brunton LL, eds., Lazo JS, Parker KL (2006) "Goodman & Gilman's the Pharmacological Basis of Therapeutics." New York, NY: McGraw-Hill
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Cerner Multum, Inc. "Australian Product Information."
Drug and food interactions
sodium sulfate food
Applies to: magnesium sulfate / potassium chloride / sodium sulfate
ADJUST DOSING INTERVAL: Bowel cleansing products can increase the gastrointestinal transit rate. Oral medications administered within one hour of the start of administration of the bowel cleansing solution may be flushed from the gastrointestinal tract and not properly absorbed.
MANAGEMENT: Patients should be advised that absorption of oral medications may be impaired during bowel cleansing treatment. Oral medications (e.g., anticonvulsants, oral contraceptives, antidiabetic agents, antibiotics) should not be administered during and within one hour of starting bowel cleansing treatment whenever possible. However, if concomitant use cannot be avoided, monitoring for reduced therapeutic effects may be advisable.
References
- "Product Information. Golytely (polyethylene glycol 3350 with electrolytes)." Braintree
- (2022) "Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate)." Ferring Pharmaceuticals Inc
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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