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Drug Interactions between magnesium sulfate / potassium chloride / sodium sulfate and methdilazine

This report displays the potential drug interactions for the following 2 drugs:

  • magnesium sulfate/potassium chloride/sodium sulfate
  • methdilazine

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Interactions between your drugs

Major

potassium chloride methdilazine

Applies to: magnesium sulfate / potassium chloride / sodium sulfate and methdilazine

The following interaction applies only if you are taking potassium in a solid formulation (i.E., tablet or capsule swallowed whole):

Talk to your doctor before using potassium oral tablets or capsules together with methdilazine. Depending on the dose of methdilazine and your overall physical health, combining these medications may increase the irritant effects of potassium on your stomach and upper intestine. This can rarely result in ulcers, bleeding, and other gastrointestinal injury. Contact your doctor immediately if you develop severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools during treatment with these medications. Alternatively, a liquid formulation of potassium may be considered when used in combination with methdilazine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

methdilazine sodium sulfate

Applies to: methdilazine and magnesium sulfate / potassium chloride / sodium sulfate

Methdilazine can occasionally cause seizures, especially if you are elderly, alcoholic, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system like a brain tumor or head trauma. The risk is also increased if you have low blood levels of electrolytes such as calcium, magnesium, potassium or sodium, which can occur with bowel cleansing preparations or excessive use of medications that have a laxative effect. You should use sodium sulfate exactly as prescribed by your doctor, and drink plenty of clear liquids before, during, and after the cleansing process to avoid becoming dehydrated. Your doctor may be able to recommend specific fluids you can drink before starting sodium sulfate to help maintain your electrolyte levels. Contact your doctor if you experience signs and symptoms of low electrolyte levels such as weakness, tiredness, drowsiness, dizziness, confusion, tingling, numbness, muscle pain, cramps, nausea, or vomiting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

sodium sulfate food

Applies to: magnesium sulfate / potassium chloride / sodium sulfate

Oral medications may not be properly absorbed when they are taken within one hour before starting sodium sulfate for bowel cleansing. Talk to your doctor or pharmacist to see if you should adjust the dosing schedule of your other medications before you begin bowel cleansing treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.