Skip to main content

Drug Interactions between Lufyllin and mosunetuzumab

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

dyphylline mosunetuzumab

Applies to: Lufyllin (dyphylline) and mosunetuzumab

MONITOR: Coadministration with mosunetuzumab may increase the plasma concentrations of drugs that are substrates of CYP450 isoenzymes. Initiation of mosunetuzumab treatment causes transient release of cytokines that may suppress CYP450 isoenzymes, although the potential for interaction has not been studied. According to the manufacturer, the highest drug-drug interaction risk would be after the first dose of the first cycle, up to 14 days after the second 60 mg dose on the first day of the second cycle, as well as during and after cytokine release syndrome.

MANAGEMENT: Caution is advised when mosunetuzumab is prescribed to patients receiving drugs that are metabolized by CYP450 isoenzymes, particularly those with a narrow therapeutic index such as carbamazepine, colchicine, cyclosporine, disopyramide, phenytoin, quinidine, theophylline, warfarin, macrolide immunosuppressants, vinca alkaloids, and some narcotic analgesics. Clinical laboratory monitoring are recommended following the initiation of mosunetuzumab, and the individual dosage of the concomitant agents adjusted as needed.

References

  1. (2022) "Product Information. Lunsumio (mosunetuzumab)." Genentech

Switch to consumer interaction data

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer