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Drug Interactions between Lufyllin-400 and probenecid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

probenecid dyphylline

Applies to: probenecid and Lufyllin-400 (dyphylline)

Probenecid may inhibit the renal elimination of dyphylline. Dyphylline concentrations and risk of toxicity may be significantly increased. The clinical significance is unknown, as data are based on single-dose studies. Theophylline pharmacokinetics do not appear to be affected by probenecid and may be considered as an alternative.

References

  1. Acara M, Carr EA Jr, Terry EN (1987) "Probenecid inhibition of the renal excretion of dyphyllin in chicken, rat and man." J Pharm Pharmacol, 39, p. 526-30
  2. Nadai M, Apichartpichean R, Hasegawa T, Nabeshima T (1992) "Pharmacokinetics and the effect of probenecid on the renal excretion mechanism of diprophylline." J Pharm Sci, 81, p. 1024-7
  3. May DC, Jarboe CH (1983) "Effect of probenecid on dyphylline elimination." Clin Pharmacol Ther, 33, p. 822-5

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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