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Drug Interactions between lorlatinib and Vfend

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

voriconazole lorlatinib

Applies to: Vfend (voriconazole) and lorlatinib

Voriconazole may significantly increase the blood levels of lorlatinib. This may increase the risk of serious side effects such as seizures, hallucinations, cognitive problems (e.G., confusion, forgetfulness, difficulty concentrating), mood disorders (e.G., depression), sleep impairment, increases in cholesterol and triglycerides, slow or abnormal heartbeats, and inflammation of the lungs. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should contact your doctor if you experience dizziness, lightheadedness, abnormal heartbeats, or any new or worsening lung problems such as difficulty breathing, shortness of breath, cough, or fever. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

lorlatinib food

Applies to: lorlatinib

Do not consume grapefruit or grapefruit juice during treatment with lorlatinib. Grapefruit juice can significantly increase the blood levels and effects of lorlatinib, which may result in a greater risk of side effects. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

voriconazole food

Applies to: Vfend (voriconazole)

You may experience reduced absorption of voriconazole in the presence of food. Take voriconazole on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer