Drug Interactions between lopinavir / ritonavir and lorlatinib

Ritonavir may significantly increase the blood levels of lorlatinib. This may increase the risk of serious side effects such as seizures, hallucinations, cognitive problems (e.G., confusion, forgetfulness, difficulty concentrating), mood disorders (e.G., depression), sleep impairment, increases in cholesterol and triglycerides, slow or abnormal heartbeats, and inflammation of the lungs. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should contact your doctor if you experience dizziness, lightheadedness, abnormal heartbeats, or any new or worsening lung problems such as difficulty breathing, shortness of breath, cough, or fever. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Lorlatinib may reduce the blood levels of lopinavir, which may make the medication less effective in treating HIV infection. Using lorlatinib with lopinavir may also increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You should seek immediate medical attention if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. Contact your doctor if your condition worsens or you develop new infections during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.