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Can you take Little Tummys Laxative Drops with Vepdegestrant?

1 drug interaction and 6 additional warnings found for the following 2 drugs:

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Drug interactions

Moderate drug interactions

Moderate:

senna vepdegestrant

Applies to: Little Tummys Laxative Drops (senna) and vepdegestrant

Vepdegestrant can cause an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. The risk is increased if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances, such as low blood levels of magnesium or potassium. These electrolyte disturbances can occur with bowel cleansing preparations or excessive use of medications that have a laxative effect, such as senna. Do not exceed the dose and duration recommended on the product label or prescribed by your doctor. You should seek immediate medical attention if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether taken together or separately. In addition, you should let your doctor know if you experience signs and symptoms of low magnesium or potassium blood level such as weakness, tiredness, drowsiness, dizziness, confusion, tingling, numbness, muscle pain, cramps, nausea, or vomiting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

Moderate food/lifestyle interactions

Moderate:

vepdegestrant Food/Lifestyle

Applies to: vepdegestrant

Grapefruit juice may increase the blood levels and effects of vepdegestrant. This may increase the risk of side effects associated with vepdegestrant. You should avoid consuming grapefruit, grapefruit juice, or products that contain grapefruit during treatment with vepdegestrant. Food can significantly increase the blood levels of vepdegestrant. You should take vepdegestrant with food exactly as directed by your doctor. Swallow the tablet as a whole. Do not chew, crush, dissolve, or split it. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate:

senna multivitamins with minerals

Applies to: Little Tummys Laxative Drops (senna)

Chronic use of senna may reduce your body's ability to absorb certain vitamins (A, D, E, and K) and minerals like calcium. To reduce the risk of diminished absorption of multivitamins with minerals, it is best to use senna only occasionally or for short periods. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Disease interactions

4 potential interactions Applies to: 4 conditions, including Inflammatory Bowel Disease, Bleeding Disorder, Appendicitis, and Gastrointestinal Obstruction.

Appendicitis

Major:

Little Tummys Laxative Drops

The senna in Little Tummys Laxative Drops has a major potential interaction with Appendicitis.

The use of stimulant laxatives is contraindicated in patients with or who may have acute surgical abdomen or appendicitis. These patients may be candidates for emergency surgery. Stimulant laxatives should also not be administered to patients with abdominal pain, particularly if the cause has not been determined.

Bleeding Disorder

Major:

Little Tummys Laxative Drops

The senna in Little Tummys Laxative Drops has a major potential interaction with Bleeding Disorder.

The use of stimulant laxatives is contraindicated in patients with anal or rectal fissures. These preparations may cause irritation, burning sensation, and proctitis.

Gastrointestinal Obstruction

Major:

Little Tummys Laxative Drops

The senna in Little Tummys Laxative Drops has a major potential interaction with Gastrointestinal Obstruction.

The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

Inflammatory Bowel Disease

Major:

Little Tummys Laxative Drops

The senna in Little Tummys Laxative Drops has a major potential interaction with Inflammatory Bowel Disease.

The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

More resources

Little Tummys Laxative Drops

A total of 269 drugs are known to interact with Little Tummys Laxative Drops.

vepdegestrant

A total of 349 drugs are known to interact with vepdegestrant.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.