Drug Interactions between linvoseltamab and nimodipine
This report displays the potential drug interactions for the following 2 drugs:
- linvoseltamab
- nimodipine
Interactions between your drugs
niMODipine linvoseltamab
Applies to: nimodipine and linvoseltamab
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with linvoseltamab may increase the plasma concentrations of drugs that are substrates of CYP450 isoenzymes. Initiation of linvoseltamab treatment causes the transient release of cytokines that may suppress CYP450 isoenzymes; however, the potential for drug-drug interactions due to this effect has not been clinically evaluated. According to the manufacturer, increased exposure to CYP450 substrate(s) is more likely from the start of linvoseltamab therapy (including the initial step-up dosing schedule) through 14 days after the initial 200 mg dose, as well as during and following cytokine release syndrome. Increased exposure to the affected CYP450 substrate(s) may increase the risk of substrate-related adverse effects.
MANAGEMENT: Caution is advised when linvoseltamab is coadministered with drugs that are metabolized by CYP450 isoenzymes, particularly those with a narrow therapeutic range, and where minimal changes to concentration may lead to significant adverse reactions (e.g. carbamazepine, colchicine, cyclosporine, disopyramide, phenytoin, quinidine, theophylline, warfarin, macrolide immunosuppressants, vinca alkaloids, and some narcotic analgesics). Clinical and/or laboratory monitoring are recommended, particularly at the initial phase of treatment with linvoseltamab as well as during and after cytokine release syndrome. Individual product labeling for the CYP450 substrate(s) should be consulted for specific dosage adjustment recommendations.
Drug and food/lifestyle interactions
niMODipine food/lifestyle
Applies to: nimodipine
You should avoid or limit the consumption of grapefruit and grapefruit juice if you are receiving treatment with niMODipine. Grapefruit juice can significantly increase the blood levels and effects of medications like niMODipine. You may be more likely to experience side effects such as headache, low blood pressure, irregular heartbeat, swelling, and fluid retention. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
niMODipine food/lifestyle
Applies to: nimodipine
NiMODipine and ethanol (alcohol) may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
niMODipine food/lifestyle
Applies to: nimodipine
Using niMODipine together with multivitamin with minerals can decrease the effects of niMODipine. Talk with your doctor before using niMODipine and multivitamin with minerals together. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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