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Drug Interactions between linvoseltamab and midostaurin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

midostaurin linvoseltamab

Applies to: midostaurin and linvoseltamab

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with linvoseltamab may increase the plasma concentrations of drugs that are substrates of CYP450 isoenzymes. Initiation of linvoseltamab treatment causes the transient release of cytokines that may suppress CYP450 isoenzymes; however, the potential for drug-drug interactions due to this effect has not been clinically evaluated. According to the manufacturer, increased exposure to CYP450 substrate(s) is more likely from the start of linvoseltamab therapy (including the initial step-up dosing schedule) through 14 days after the initial 200 mg dose, as well as during and following cytokine release syndrome. Increased exposure to the affected CYP450 substrate(s) may increase the risk of substrate-related adverse effects.

MANAGEMENT: Caution is advised when linvoseltamab is coadministered with drugs that are metabolized by CYP450 isoenzymes, particularly those with a narrow therapeutic range, and where minimal changes to concentration may lead to significant adverse reactions (e.g. carbamazepine, colchicine, cyclosporine, disopyramide, phenytoin, quinidine, theophylline, warfarin, macrolide immunosuppressants, vinca alkaloids, and some narcotic analgesics). Clinical and/or laboratory monitoring are recommended, particularly at the initial phase of treatment with linvoseltamab as well as during and after cytokine release syndrome. Individual product labeling for the CYP450 substrate(s) should be consulted for specific dosage adjustment recommendations.

Drug and food/lifestyle interactions

Major

midostaurin food/lifestyle

Applies to: midostaurin

Midostaurin should be taken with food to help with its absorption. Do not consume grapefruit or grapefruit juice during treatment, as it can significantly increase the blood levels of midostaurin. You may be more likely to experience side effects such as nausea; vomiting; diarrhea; swelling; high blood sugar; heart rhythm abnormalities; and impaired bone marrow function resulting in low numbers of different types of blood cells, which can increase the risk of anemia, bleeding problems, and infections. You should seek medical attention if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain and burning during urination. Talk to your healthcare provider if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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