Drug Interactions between Lexapro and tryptophan
This report displays the potential drug interactions for the following 2 drugs:
- Lexapro (escitalopram)
- tryptophan
Interactions between your drugs
tryptophan escitalopram
Applies to: tryptophan and Lexapro (escitalopram)
GENERALLY AVOID: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.
MANAGEMENT: The concomitant use of serotonin reuptake inhibitors and tryptophan should be avoided.
References
- (2001) "Product Information. Zoloft (sertraline)." Roerig Division
- (2001) "Product Information. Prozac (fluoxetine)." Dista Products Company
- (2001) "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories
- (2001) "Product Information. Paxil (paroxetine)." GlaxoSmithKline
- (2001) "Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc
- (2001) "Product Information. Celexa (citalopram)." Forest Pharmaceuticals
- (2002) "Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals
- (2004) "Product Information. Cymbalta (duloxetine)." Lilly, Eli and Company
- (2008) "Product Information. Pristiq (desvenlafaxine)." Wyeth Laboratories
- (2009) "Product Information. Savella (milnacipran)." Forest Pharmaceuticals
- (2009) "Product Information. Nucynta (tapentadol)." PriCara Pharmaceuticals
- (2011) "Product Information. Viibryd (vilazodone)." Trovis Pharmaceuticals LLC
- (2013) "Product Information. Fetzima (levomilnacipran)." Forest Pharmaceuticals
- (2013) "Product Information. Brintellix (vortioxetine)." Takeda Pharmaceuticals America
Drug and food interactions
escitalopram food
Applies to: Lexapro (escitalopram)
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References
- Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
- (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
- (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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