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Drug Interactions between levobunolol ophthalmic and Piloptic-4

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

levobunolol ophthalmic pilocarpine ophthalmic

Applies to: levobunolol ophthalmic and Piloptic-4 (pilocarpine ophthalmic)

Limited data indicate that addition of pilocarpine to levobunolol eye drops significantly decreases ocular absorption of levobunolol. The ocular absorption of levobunolol is pH-dependent, and pilocarpine significantly buffers levobunolol ophthalmic solutions. At acidic pH, the ocular absorption of levobunolol in the presence of pilocarpine may be enhanced by the use of sulfosuccinates.

References

  1. Tangliu DD, Richman JB "The effect of pilocarpine on ocular levobunolol absorption from ophthalmic solutions." J Ocul Pharmacol 10 (1994): 605-15

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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