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Drug Interactions between levamlodipine and rapacuronium

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

rapacuronium levamlodipine

Applies to: rapacuronium and levamlodipine

MONITOR: Some calcium channel blockers may enhance the neuromuscular blocking properties of nondepolarizing muscle relaxants. The mechanism is not known, but may involve blockage of calcium channels on skeletal muscle. Data are available for verapamil, diltiazem, nicardipine, atracurium, vecuronium, and pancuronium.

MANAGEMENT: Patients should be closely monitored for prolonged neuromuscular blockade. Reduced doses of muscle relaxants may be necessary. Profound neuromuscular blockade may be reversed by neostigmine or edrophonium.

References (4)
  1. Carlos R, Erill S (1986) "Therapeutic Rounds." Clin Ther, 9, p. 22-3
  2. Wali FA (1987) "Interaction of verapamil with d-tubocurarine and cholinergic agonists at the avian neuromuscular junction." Acta Anaesthesiol Scand, 31, p. 15-20
  3. Sekerci S, Tulunay M (1996) "Interactions of calcium channel blockers with non-depolarising muscle relaxants in vitro." Anaesthesia, 51, p. 140-4
  4. Saitoh Y, Makita K, Tanaka H (1997) "Diltiazem and vecuronium: neuromuscular and cardiovascular effects." Can J Anaesth, 44, p. 99

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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