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Drug Interactions between letermovir and voriconazole

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

voriconazole letermovir

Applies to: voriconazole and letermovir

Consumer information for this interaction is not currently available.

MONITOR CLOSELY: Coadministration with letermovir may significantly decrease the plasma concentrations and efficacy of voriconazole. The proposed mechanism is induction of CYP450 2C9 and/or 2C19, isoenzymes primarily responsible for the metabolic clearance of voriconazole. According to the product labeling, voriconazole peak plasma concentration (Cmax), systemic exposure (AUC) and concentration at 12 hours post-dose (C12hr) decreased by an average of 39%, 44% and 51%, respectively, when voriconazole 200 mg orally twice daily was coadministered with letermovir 480 mg orally once daily. Subtherapeutic levels of voriconazole may occur.

MANAGEMENT: Close clinical and laboratory monitoring are advised if letermovir is used concomitantly with voriconazole. Some authorities recommend avoiding this combination. Dosage adjustments may be appropriate for voriconazole whenever letermovir is added to or withdrawn from therapy.

Drug and food interactions

Moderate

voriconazole food

Applies to: voriconazole

You may experience reduced absorption of voriconazole in the presence of food. Take voriconazole on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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