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Drug Interactions between letermovir and pralsetinib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

letermovir pralsetinib

Applies to: letermovir and pralsetinib

Letermovir may increase the blood levels of pralsetinib. Elevated levels of pralsetinib can increase the risk and/or severity of side effects including lung problems, liver problems, high blood pressure, fatigue, muscle and joint pain, and bleeding complications. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

pralsetinib food

Applies to: pralsetinib

Pralsetinib should be taken on an empty stomach, at least 2 hours after or 1 hour before a meal. Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with pralsetinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of pralsetinib. This may increase the risk and/or severity of serious side effects such as lung problems, high blood pressure, liver problems, bleeding, fatigue, muscle pains, or constipation. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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