Can you take Lenacapavir with Nirogacestat?
1 drug interaction and 4 additional warnings found for the following 2 drugs:
- lenacapavir
- nirogacestat
Drug interactions
Major drug interactions
Major:
lenacapavir nirogacestat
Applies to: lenacapavir and nirogacestat
Lenacapavir may significantly increase the blood levels and effects of nirogacestat. This can increase the risk and/or severity of side effects such as diarrhea, liver problems, new non-melanoma skin cancers, electrolyte disturbances, and in women who can become pregnant, ovarian problems. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
nirogacestat Food/Lifestyle
Applies to: nirogacestat
Do not consume grapefruit, grapefruit juice, Seville oranges, or starfruit during treatment with nirogacestat. Doing so can significantly increase the blood levels of nirogacestat and increase the risk and/or severity of side effects such as diarrhea, liver problems, new non-melanoma skin cancers, electrolyte disturbances, and in women who can become pregnant, ovarian problems. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
3 potential interactions Applies to: 2 conditions, including Liver Disease and Renal Dysfunction.
Liver Disease
Moderate:
lenacapavir
Lenacapavir has a moderate potential interaction with Liver Disease.
Lenacapavir has not been studied in patients with severe hepatic impairment (Child-Pugh Class C).
Moderate:
nirogacestat
Nirogacestat has a moderate potential interaction with Liver Disease.
Nirogacestat should be used with caution in patients with severe liver dysfunction as there is insufficient data available to characterize the pharmacokinetics of this drug in this population.
Renal Dysfunction
Moderate:
lenacapavir
Lenacapavir has a moderate potential interaction with Renal Dysfunction.
Lenacapavir has not been studied in patients with end stage renal disease (estimated creatinine clearance less than 15 mL per minute).
Report options
More resources
lenacapavir
A total of 496 drugs are known to interact with lenacapavir.
- Lenacapavir is in the drug class miscellaneous antivirals.
- Lenacapavir is used to treat the following conditions:
nirogacestat
A total of 373 drugs are known to interact with nirogacestat.
- Nirogacestat is in the drug class miscellaneous antineoplastics.
- Nirogacestat is used to treat Desmoid Tumor.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.