Interactions between Lanreotide and Lutathera

Lanreotide has a moderate potential interaction with Adrenal Insufficiency.

Treatment with somatostatin analogs may suppress the pituitary hormones other than GH/IGF-1. It is recommended to monitor pituitary function prior to initiation of therapy and periodically during treatment, as clinically appropriate. Patients should be monitored for and instructed on the signs and symptoms of adrenal insufficiency during therapy. If adrenal insufficiency is suspected it should be confirmed and treated per standard of care with exogenous glucocorticoids at replacement doses.

The lutetium Lu 177 dotatate in Lutathera has a moderate potential interaction with Bone Marrow Depression/Low Blood Counts.

The use of lutetium Lu 177 dotatate may increase the risk of developing myelosuppression. Care should be exercised when using this agent in immunocompromised patients. It is recommended to monitor blood cell counts. Withhold, reduce dose, or permanently discontinue based on severity of adverse reaction.

Lanreotide has a moderate potential interaction with Diabetes Mellitus.

Elevations in blood glucose levels have been reported with the use of somatostatin analogs. Cushing's disease patients with poor glycemic control may be at a higher risk of developing severe hyperglycemia and associated complications, e.g., ketoacidosis. It is recommended to assess the glycemic status of hemoglobin A1C prior to starting treatment with these agents. Self-monitoring of blood glucose and/or FPG assessments should be done every week for the first two to three months and periodically thereafter, as clinically appropriate, as well as over the first two to four weeks after any dose increase. If uncontrolled hyperglycemia persists, despite appropriate medical management, the dose of these agents should be reduced or discontinued.

Lanreotide has a moderate potential interaction with Gallbladder Disease.

Somatostatin analogs may reduce gallbladder motility and lead to gallstones formation. It is recommended to assess the gallbladder prior to starting therapy and periodically thereafter.

Lanreotide has a moderate potential interaction with Heart Disease.

Bradycardia has been reported with the use of somatostatin analogs. It is recommended to carefully monitor patients with cardiac disorders for the development of bradycardia. Dose adjustments of beta-blockers, calcium channel blockers, or correction of electrolyte disturbances may be necessary. Care should be taken when initiating treatment with these agents in patients with bradycardia.

The lutetium Lu 177 dotatate in Lutathera has a moderate potential interaction with Immunodeficiency.

The use of lutetium Lu 177 dotatate may increase the risk of developing myelosuppression. Care should be exercised when using this agent in immunocompromised patients. It is recommended to monitor blood cell counts. Withhold, reduce dose, or permanently discontinue based on severity of adverse reaction.

Lanreotide has a moderate potential interaction with Liver Disease.

In clinical trials, a reduced clearance of lanreotide was observed in subjects with moderate to severe hepatic impairment. Patients with moderate to severe hepatic impairment should begin treatment with lanreotide 60 mg. Caution should be exercised when using this agent in patients with moderate or severe hepatic impairment for an extended dosing interval.

The lutetium Lu 177 dotatate in Lutathera has a moderate potential interaction with Liver Disease.

Lutetium Lu 177 dotatate does not undergo hepatic metabolism. No dose adjustment is recommended for patients with mild or moderate hepatic impairment. Care is recommended when using lutetium Lu 177 dotatate in patients with severe hepatic impairment (total bilirubin > 3 times upper limit of normal and any AST) as its safety has not been studied in these patients. Monitor transaminases, bilirubin and serum albumin during treatment.

Lanreotide has a moderate potential interaction with Renal Dysfunction.

Lanreotide has not been studied in patients with mild, moderate and severe renal failure. It is recommended to start patients with moderate and severe renal impairment at a lower dose as clinically appropriate.

The lutetium Lu 177 dotatate in Lutathera has a moderate potential interaction with Renal Dysfunction.

Lutetium Lu 177 dotatate predominantly undergoes renal excretion. No dose adjustment is recommended for patients with mild to moderate renal impairment. It is recommended to assess renal function frequently in patients with mild to moderate impairment during therapy with this agent. . Monitor serum creatinine and calculated creatinine clearance. The safety of lutetium Lu 177 dotatate in patients with severe renal impairment or end-stage renal disease has not been studied

Lanreotide has a moderate potential interaction with Thyroid Disease.

Slight decreases in thyroid function have been seen during treatment with lanreotide. Care should be taken when using this agent in patients with thyroid dysfunctions and it is recommended to monitor thyroid function where clinically indicated.

Lanreotide has a moderate potential interaction with Underactive Thyroid.

Bradycardia has been reported with the use of somatostatin analogs. It is recommended to carefully monitor patients with cardiac disorders for the development of bradycardia. Dose adjustments of beta-blockers, calcium channel blockers, or correction of electrolyte disturbances may be necessary. Care should be taken when initiating treatment with these agents in patients with bradycardia.