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Drug Interactions between landiolol and tasimelteon

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

tasimelteon landiolol

Applies to: tasimelteon and landiolol

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Coadministration with beta-blockers may diminish the therapeutic effects of tasimelteon. Beta-blockers have been shown to reduce the production of melatonin via inhibition of beta-1 adrenergic receptors; therefore, the efficacy of tasimelteon, which acts as an agonist at melatonin MT1 and MT2 receptors, may be reduced.

MANAGEMENT: Product labeling for tasimelteon suggests avoiding the nighttime administration of beta-blockers.

Drug and food interactions

Moderate

tasimelteon food

Applies to: tasimelteon

Food can delay the absorption of tasimelteon, which may increase the amount of time it takes for the medication to work. You should take tasimelteon without food at the same time each night before going to bed. If you are a smoker, there is a possibility that tasimelteon may not work as well for you due to reduced blood levels of the medication in smokers compared to nonsmokers. You should avoid or limit the use of alcohol while being treated with tasimelteon. It can increase some of the side effects including dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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