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Drug Interactions between landiolol and nitroglycerin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

nitroglycerin landiolol

Applies to: nitroglycerin and landiolol

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Concomitant use of landiolol with negative inotropes, medications that slow heart rate or cardiac conduction should be done with caution. Coadministration may result in additive suppression of cardiac function, atrioventricular (AV) conduction abnormalities, prolonged PR interval, and potentially additive heart-rate and blood pressure lowering effects. Landiolol alone is associated with increased risk of bradycardia and heart block, and therefore coadministration with these agents may potentiate these effects.

MANAGEMENT: If coadministration is clinically necessary, careful titration of the landiolol infusion and close hemodynamic monitoring is advised. Consultation with package labeling and relevant institutional protocols may be advisable for further guidance.

Drug and food interactions

Moderate

nitroglycerin food

Applies to: nitroglycerin

Nitroglycerin and ethanol (alcohol) may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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