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Drug Interactions between lactulose and Rowasa Sulfite Free

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

lactulose mesalamine

Applies to: lactulose and Rowasa Sulfite Free (mesalamine)

Coadministration with lactulose or similar preparations may cause a reduction in the release of mesalamine from some oral tablet formulations of mesalamine. Bacterial metabolism of lactulose may lower the stool pH which may prevent the release of mesalamine from some oral tablet formulations. This interaction does not apply to all mesalamine preparations. Use of lactulose or similar preparations with certain oral tablet formulations of mesalamine should generally be avoided. Please consult the manufacturer's individual product labeling for more specific recommendations and guidance.

References (3)
  1. Hussain FN, Ajjan RA, Moustafa M, Weir NW, Riley SA (1998) "Mesalazine release from a pH dependent formulation: effects of omeprazole and lactulose co-administration." Br J Clin Pharmacol, 46, p. 173-5
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. Cerner Multum, Inc. "Australian Product Information."

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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