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Drug Interactions between lactulose and neomycin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

neomycin lactulose

Applies to: neomycin and lactulose

On theoretical grounds and based on limited experimental data in rats, coadministration with neomycin may presumably reduce the effectiveness of lactulose in the treatment of portal-systemic encephalopathy by eliminating certain colonic bacteria necessary for the degradation of lactulose to organic acids. However, the relevance of this interaction has not been fully elucidated. Clinical data do not appear to support a significant effect of neomycin on lactulose-induced reduction of colonic pH, and concomitant use has resulted in positive effects on various therapeutic markers of portal-systemic encephalopathy.

References (4)
  1. Conn HO (1972) "Interactions of lactulose and neomycin." Drugs, 4, p. 4-6
  2. (2002) "Product Information. Chronulac (lactulose)." Hoechst Marion Roussel
  3. (2002) "Product Information. Cephulac (lactulose)." Hoechst Marion Roussel
  4. (2012) "Product Information. Enulose (lactulose)." United Research Laboratories/Mutual Pharmaceutical Company

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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