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Can you take Lactated Ringers Injection with Sodium biphosphate / sodium phosphate?

No drug interactions found, but 20 warnings to review for the following 2 drugs:

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Drug interactions

There were no interactions found between Lactated Ringers Injection and sodium biphosphate / sodium phosphate. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Food/lifestyle interactions

Moderate food/lifestyle interactions

Moderate:

sodium biphosphate Food/Lifestyle

Applies to: sodium biphosphate / sodium phosphate

Oral medications may not be properly absorbed when they are taken within one hour before starting sodium biphosphate for bowel cleansing.

Talk to your doctor or pharmacist to see if you should adjust the dosing schedule of your other medications before you begin bowel cleansing treatment.

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Disease interactions

19 potential interactions Applies to: 14 conditions, including Heart Failure, Hypokalemia, Inflammatory Bowel Disease, Hypocalcemia, and Diabetes Mellitus.

Dehydration

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Dehydration.

The use of sodium phosphates is contraindicated in patients with congenital megacolon, intestinal obstruction, imperforate anus, active inflammatory disease or congestive heart failure. Serious, potentially life-threatening electrolyte imbalance such as hypocalcemia and hyperphosphatemia can result with prolonged or excessive use of phosphate laxatives. Hypernatremia and dehydration can occur due to improper dilution of hypertonic saline laxatives. Therapy with sodium phosphates should be administered cautiously and frequency of administration limited in patients with renal dysfunction, colostomy, cardiac dysfunction, or electrolyte imbalance. Clinical monitoring of electrolyte concentrations is recommended.

Diabetes Mellitus

Moderate:

Lactated Ringers Injection

The LVP solution in Lactated Ringers Injection has a moderate potential interaction with Diabetes Mellitus.

LVP solution for peritoneal dialysis contains dextrose and may increase the risk for hyperglycemia in patients with impaired glucose tolerance. Patients may require initiation or modification of antidiabetic therapy during treatment with these solutions. Blood glucose should me monitored.

Fluid Retention

Major:

Lactated Ringers Injection

The LVP solution in Lactated Ringers Injection has a major potential interaction with Fluid Retention.

Sodium chloride can induce sodium and water retention and result in hypernatremia, hypokalemia, edema and aggravation of congestive heart failure. Therapy with sodium- containing agents should be administered with extreme caution, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states where there is edema with sodium retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with sodium- containing agents is recommended.

Major:

sodium biphosphate / sodium phosphate

The sodium phosphate in sodium biphosphate / sodium phosphate has a major potential interaction with Fluid Retention.

Alkalinizing agents containing sodium can induce sodium and water retention and result in hypernatremia, hypokalemia, hyperosmolality, edema and aggravation of congestive heart failure. Therapy with sodium- containing alkalinizing agents should not be used in patients with hypernatremia or fluid retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with alkalinizing agents is recommended.

Gastrointestinal Obstruction

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Gastrointestinal Obstruction.

The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Gastrointestinal Obstruction.

The use of sodium phosphates is contraindicated in patients with congenital megacolon, intestinal obstruction, imperforate anus, active inflammatory disease or congestive heart failure. Serious, potentially life-threatening electrolyte imbalance such as hypocalcemia and hyperphosphatemia can result with prolonged or excessive use of phosphate laxatives. Hypernatremia and dehydration can occur due to improper dilution of hypertonic saline laxatives. Therapy with sodium phosphates should be administered cautiously and frequency of administration limited in patients with renal dysfunction, colostomy, cardiac dysfunction, or electrolyte imbalance. Clinical monitoring of electrolyte concentrations is recommended.

Heart Failure

Major:

Lactated Ringers Injection

The LVP solution in Lactated Ringers Injection has a major potential interaction with Heart Failure.

Sodium chloride can induce sodium and water retention and result in hypernatremia, hypokalemia, edema and aggravation of congestive heart failure. Therapy with sodium- containing agents should be administered with extreme caution, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states where there is edema with sodium retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with sodium- containing agents is recommended.

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Heart Failure.

The use of sodium phosphates is contraindicated in patients with congenital megacolon, intestinal obstruction, imperforate anus, active inflammatory disease or congestive heart failure. Serious, potentially life-threatening electrolyte imbalance such as hypocalcemia and hyperphosphatemia can result with prolonged or excessive use of phosphate laxatives. Hypernatremia and dehydration can occur due to improper dilution of hypertonic saline laxatives. Therapy with sodium phosphates should be administered cautiously and frequency of administration limited in patients with renal dysfunction, colostomy, cardiac dysfunction, or electrolyte imbalance. Clinical monitoring of electrolyte concentrations is recommended.

Hyperkalemia

Major:

sodium biphosphate / sodium phosphate

The sodium phosphate in sodium biphosphate / sodium phosphate has a major potential interaction with Hyperkalemia.

The use of phosphates is in general contraindicated in conditions where high potassium, high phosphate, or low calcium may be encountered such as hypoparathyroidism, osteomalacia, acute pancreatitis, or chronic renal disease.

Hypernatremia

Major:

Lactated Ringers Injection

The LVP solution in Lactated Ringers Injection has a major potential interaction with Hypernatremia.

Sodium chloride can induce sodium and water retention and result in hypernatremia, hypokalemia, edema and aggravation of congestive heart failure. Therapy with sodium- containing agents should be administered with extreme caution, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states where there is edema with sodium retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with sodium- containing agents is recommended.

Major:

sodium biphosphate / sodium phosphate

The sodium phosphate in sodium biphosphate / sodium phosphate has a major potential interaction with Hypernatremia.

Alkalinizing agents containing sodium can induce sodium and water retention and result in hypernatremia, hypokalemia, hyperosmolality, edema and aggravation of congestive heart failure. Therapy with sodium- containing alkalinizing agents should not be used in patients with hypernatremia or fluid retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with alkalinizing agents is recommended.

Hypocalcemia

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Hypocalcemia.

The use of phosphates is in general contraindicated in conditions where high potassium, high phosphate, or low calcium may be encountered such as hypoparathyroidism, osteomalacia, acute pancreatitis, or chronic renal disease.

Hypokalemia

Major:

Lactated Ringers Injection

The LVP solution in Lactated Ringers Injection has a major potential interaction with Hypokalemia.

Sodium chloride can induce sodium and water retention and result in hypernatremia, hypokalemia, edema and aggravation of congestive heart failure. Therapy with sodium- containing agents should be administered with extreme caution, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states where there is edema with sodium retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with sodium- containing agents is recommended.

Hypoparathyroidism

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Hypoparathyroidism.

Therapy with phosphates should be administered with extreme caution in patients with hyperphosphatemia (hypoparathyroidism or severe renal impairment). Elevated serum concentrations of phosphate and calcium can exceed the solubility level and result in calcium-phosphate precipitates that deposit in vascular and renal systems as well as other soft tissues of the body. Clinical monitoring of serum calcium and phosphate concentrations is necessary.

Inflammatory Bowel Disease

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Inflammatory Bowel Disease.

The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Inflammatory Bowel Disease.

The use of sodium phosphates is contraindicated in patients with congenital megacolon, intestinal obstruction, imperforate anus, active inflammatory disease or congestive heart failure. Serious, potentially life-threatening electrolyte imbalance such as hypocalcemia and hyperphosphatemia can result with prolonged or excessive use of phosphate laxatives. Hypernatremia and dehydration can occur due to improper dilution of hypertonic saline laxatives. Therapy with sodium phosphates should be administered cautiously and frequency of administration limited in patients with renal dysfunction, colostomy, cardiac dysfunction, or electrolyte imbalance. Clinical monitoring of electrolyte concentrations is recommended.

Pancreatitis

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Pancreatitis.

The use of phosphates is in general contraindicated in conditions where high potassium, high phosphate, or low calcium may be encountered such as hypoparathyroidism, osteomalacia, acute pancreatitis, or chronic renal disease.

Phosphate Imbalance

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Phosphate Imbalance.

The use of sodium phosphates is contraindicated in patients with congenital megacolon, intestinal obstruction, imperforate anus, active inflammatory disease or congestive heart failure. Serious, potentially life-threatening electrolyte imbalance such as hypocalcemia and hyperphosphatemia can result with prolonged or excessive use of phosphate laxatives. Hypernatremia and dehydration can occur due to improper dilution of hypertonic saline laxatives. Therapy with sodium phosphates should be administered cautiously and frequency of administration limited in patients with renal dysfunction, colostomy, cardiac dysfunction, or electrolyte imbalance. Clinical monitoring of electrolyte concentrations is recommended.

Renal Dysfunction

Major:

sodium biphosphate / sodium phosphate

The sodium biphosphate and sodium phosphate in sodium biphosphate / sodium phosphate both have a major potential interaction with Renal Dysfunction.

Therapy with phosphates should be administered with extreme caution in patients with hyperphosphatemia (hypoparathyroidism or severe renal impairment). Elevated serum concentrations of phosphate and calcium can exceed the solubility level and result in calcium-phosphate precipitates that deposit in vascular and renal systems as well as other soft tissues of the body. Clinical monitoring of serum calcium and phosphate concentrations is necessary.

More resources

Lactated Ringers Injection

A total of 0 drugs are known to interact with Lactated Ringers Injection.

sodium biphosphate / sodium phosphate

A total of 430 drugs are known to interact with sodium biphosphate / sodium phosphate.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.