Drug interactions between indinavir and saquinavir
Interactions between your drugs
saquinavir ↔ indinavir
Applies to:saquinavir and indinavir
Using indinavir together with saquinavir can alter the effects of both medications. Combining these medications may increase the blood levels and effects of saquinavir and, if used together with another medication called ritonavir, may increase the blood levels and effects of indinavir. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. Contact your doctor if your condition changes or you experience increased side effects such as kidney problems, including kidney stones or back pain with or without blood in your urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
Applies to: saquinavir
Food can enhance the levels of saquinavir in your body. Saquinavir should be taken with meals or within 2 hours after eating. This will make it easier for your body to absorb the medication. Grapefruit can raise the levels of saquinavir in your body. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.
Applies to: indinavir
Large amounts of food decreases the levels of indinavir in your body. Indinavir should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal. This will make it easier for your body to absorb the medication. Take indinavir with a full glass (8 ounces) of water or skim milk. You may also drink juice, coffee, or tea with this medication. Drink at least 6 glasses of water each day to prevent kidney stones while you are taking indinavir. If you prefer to take the medication with food, eat only a light meal, such as dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.
Therapeutic duplication warnings
The recommended maximum number of medicines in the 'protease inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'protease inhibitors' category:
Drug Interaction Classification
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Do not stop taking any medications without consulting your healthcare provider.