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Drug Interactions between icatibant and moexipril

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

moexipril icatibant

Applies to: moexipril and icatibant

GENERALLY AVOID: Icatibant and angiotensin-converting enzyme (ACE) inhibitors may antagonize the pharmacological effects of one another. Icatibant is a competitive bradykinin B2 receptor antagonist. In contrast, ACE inhibitors enhance the levels of bradykinin, which is a vasodilator thought to be responsible for the characteristic symptoms of hereditary angioedema including localized swelling, inflammation, and pain. Following bradykinin challenge, intravenous administration of icatibant inhibited the development of bradykinin-induced hypotension, vasodilation, and reflex tachycardia in a dose- and time-dependent manner in healthy young subjects. Icatibant may, therefore, attenuate the antihypertensive effect of ACE inhibitors.

MANAGEMENT: Concomitant use of icatibant and ACE inhibitors should be avoided. Patients with hereditary angioedema (HAE) should generally not take ACE inhibitors because they may precipitate or exacerbate acute attacks of HAE.

References (4)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
  3. Cerner Multum, Inc. "Australian Product Information."
  4. (2011) "Product Information. Firazyr (icatibant)." Shire US Inc

Drug and food interactions

Moderate

moexipril food

Applies to: moexipril

GENERALLY AVOID: Moderate-to-high dietary intake of potassium can cause hyperkalemia in some patients who are using angiotensin converting enzyme (ACE) inhibitors. In some cases, affected patients were using a potassium-rich salt substitute. ACE inhibitors can promote hyperkalemia through inhibition of the renin-aldosterone-angiotensin (RAA) system.

MANAGEMENT: It is recommended that patients who are taking ACE inhibitors be advised to avoid moderately high or high potassium dietary intake. Particular attention should be paid to the potassium content of salt substitutes.

References (3)
  1. (2002) "Product Information. Vasotec (enalapril)." Merck & Co., Inc
  2. Good CB, McDermott L (1995) "Diet and serum potassium in patients on ACE inhibitors." JAMA, 274, p. 538
  3. Ray K, Dorman S, Watson R (1999) "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens, 13, p. 717-20

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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