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Drug Interactions between Hyperstat IV and raloxifene

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

diazoxide raloxifene

Applies to: Hyperstat IV (diazoxide) and raloxifene

Raloxifene is more than 95% protein bound. Caution should be exercised if raloxifene is coadministered with other highly protein-bound drugs. The mechanism is displacement of the drug from its protein-binding site by raloxifene. Displacement may lead to increased free plasma concentrations and potentiate toxicity of drugs affected by raloxifene. Formal in-vitro studies indicate that raloxifene did not affect the binding of warfarin, phenytoin, or tamoxifen. The clinician may want to use caution when raloxifene is used with other highly-protein bound drugs, such as diazepam, diazoxide, or lidocaine.

References

  1. (2001) "Product Information. Evista (raloxifene)." Lilly, Eli and Company
  2. (2023) "Product Information. Evista (raloxifene)." Lilly, Eli and Company
  3. (2019) "Product Information. Raloxifene (raloxifene)." Aspire Pharma Ltd
  4. (2023) "Product Information. Evista (raloxifene)." Eli Lilly Australia Pty Ltd
View all 4 references

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Drug and food interactions

Moderate

diazoxide food

Applies to: Hyperstat IV (diazoxide)

MONITOR: Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.

MANAGEMENT: Caution and close monitoring for development of hypotension is advised during coadministration of these agents. Some authorities recommend avoiding alcohol in patients receiving vasodilating antihypertensive drugs. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.

References

  1. Sternbach H (1991) "Fluoxetine-associated potentiation of calcium-channel blockers." J Clin Psychopharmacol, 11, p. 390-1
  2. Shook TL, Kirshenbaum JM, Hundley RF, Shorey JM, Lamas GA (1984) "Ethanol intoxication complicating intravenous nitroglycerin therapy." Ann Intern Med, 101, p. 498-9
  3. Feder R (1991) "Bradycardia and syncope induced by fluoxetine." J Clin Psychiatry, 52, p. 139
  4. Ellison JM, Milofsky JE, Ely E (1990) "Fluoxetine-induced bradycardia and syncope in two patients." J Clin Psychiatry, 51, p. 385-6
  5. Rodriguez de la Torre B, Dreher J, Malevany I, et al. (2001) "Serum levels and cardiovascular effects of tricyclic antidepressants and selective serotonin reuptake inhibitors in depressed patients." Ther Drug Monit, 23, p. 435-40
  6. Cerner Multum, Inc. "Australian Product Information."
  7. Pacher P, Kecskemeti V (2004) "Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?" Curr Pharm Des, 10, p. 2463-75
  8. Andrews C, Pinner G (1998) "Postural hypotension induced by paroxetine." BMJ, 316, p. 595
View all 8 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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