Skip to main content

Drug Interactions between hydrocortisone / lidocaine / psyllium topical and tocainide

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

tocainide lidocaine topical

Applies to: tocainide and hydrocortisone / lidocaine / psyllium topical

MONITOR: Coadministration of topical formulations containing lidocaine with class IB antiarrhythmic agents such as mexiletine or tocainide may have additive and potentially synergistic toxic effects. Mexiletine, tocainide and lidocaine are structural analogs, and all have antiarrhythmic effects. The clinical significance of the interaction has not been established; the degree of systemic absorption of topical lidocaine may be dependent on the duration of application and the applied surface area.

MANAGEMENT: Caution and clinical monitoring is recommended with the concomitant use of lidocaine-containing topical formulations and class IB antiarrhythmic drugs (e.g., mexiletine, tocainide). Advise patients to contact their physician if they experience adverse effects such as chest pain, palpitations, nausea, vomiting, lightheadedness, nervousness, dizziness or tremors.

References (3)
  1. (2001) "Product Information. Lidoderm (lidocaine topical)." Endo Laboratories LLC
  2. (2022) "Product Information. Oraqix (lidocaine-prilocaine topical)." Dentsply Pharmaceuticals, 1
  3. (2022) "Product Information. Diclona (diclofenac-lidocaine topical)." Terrain Pharmaceuticals, 1

Drug and food interactions

Moderate

psyllium food

Applies to: hydrocortisone / lidocaine / psyllium topical

ADJUST DOSING INTERVAL: Bulk-forming laxatives such as guar gum, psyllium, polycarbophil, or methylcellulose may affect the bioavailability of concomitantly administered substances due to their effect on the rate of gastrointestinal transit and gastric emptying.

MANAGEMENT: In general, oral medications should be administered at least 2 hours before or 2 hours after dosing of the bulk-forming laxative.

References (1)
  1. (2001) "Product Information. Metamucil (psyllium)." Procter and Gamble Pharmaceuticals

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer