Drug interactions between hydrocodone and primidone
Interactions between your drugs
primidone ↔ hydrocodone
Applies to:primidone and hydrocodone
Using HYDROcodone together with other medications that cause central nervous system depression such as primidone can lead to serious side effects including respiratory distress, coma, and even death. Additionally, primidone may reduce the blood levels of HYDROcodone in some cases, which may make the medication less effective in treating your condition. If you have been receiving treatment with HYDROcodone, adding primidone may cause you to experience unpleasant withdrawal symptoms such as watery eyes, runny nose, sneezing, yawning, excessive sweating, goose bumps, fever, chills, flushing, restlessness, irritability, anxiety, depression, pupil dilation, tremor, rapid heart beat, body aches, involuntary twitching and kicking, abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, and weight loss. On the other hand, if you have been receiving both medications, discontinuing primidone may increase the blood levels of HYDROcodone, which could lead to an overdose. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor's approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, you should avoid driving or operating hazardous machinery until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug Interaction Classification
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Do not stop taking any medications without consulting your healthcare provider.