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Drug Interactions between heroin and Trovan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

heroin (Schedule I substance) trovafloxacin

Applies to: heroin and Trovan (trovafloxacin)

ADJUST DOSING INTERVAL: Coadministration of oral trovafloxacin with intravenous morphine significantly decreases the absorption of trovafloxacin. Loss of efficacy may result. The mechanism of the interaction is not known.

MANAGEMENT: If these drugs must be coadministered, intravenous morphine should be administered at least two hours after the oral trovafloxacin dose in the fasted state and at least four hours after oral trovafloxacin in the fed state.

References (2)
  1. (2001) "Product Information. Trovan (trovafloxacin)." Pfizer U.S. Pharmaceuticals
  2. Vincent J, Hunt T, Teng RL, Robarge L, Willavize SA, Friedman HL (1998) "The pharmacokinetic effects of coadministration of morphine and trovafloxacin in healthy subjects." Am J Surg, 176, s32-8

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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