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Drug Interactions between heparin and piperacillin / tazobactam

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

piperacillin heparin

Applies to: piperacillin / tazobactam and heparin

Case reports have suggested that intravenous penicillins may intensify the effect of heparin by inhibition of platelet aggregation; however, causality has not been clearly determined. Patients should be monitored for bleeding problems. Protamine sulfate may be useful for clinically important bleeding.

References (3)
  1. Wisloff F, Larsen JP, Dahle A, Lie M, Godal HC (1983) "Effect of prophylactic high-dose treatment with ampicillin and cloxacillin on bleeding time and bleeding in patients undergoing elective vascular surgery." Scand J Haematol, 31, p. 97-101
  2. Brown CH, Natelson EA, Bradshaw W, Williams TW, Alfrey CP (1974) "The hemostatic defect produced by carbenicillin." N Engl J Med, 291, p. 265-70
  3. Tabernero JM, Corbacho RL, Sanchez S, et al. (1979) "Effects of carbenicillin on blood coagulation: a study in patients with chronic renal failure." Clin Nephrol, 11, p. 31-4

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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