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Drug Interactions between guaifenesin / oxtriphylline and tocainide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

tocainide oxtriphylline

Applies to: tocainide and guaifenesin / oxtriphylline

Tocainide causes a decrease in theophylline clearance. The result is an increase in serum theophylline concentrations and a mild increase in the serum half-life of theophylline. The magnitude of this interaction is less than for mexiletine, which has been shown to reduce theophylline plasma clearance by 40% to 45%. The mechanism of this interaction is not known. Tocainide may interact in a similar way with other xanthines. Management consists of monitoring clinical status during therapy and checking serum theophylline levels as necessary. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physician.

References (2)
  1. Loi C, Wei X, Parker B, Vestal R (1992) "Effect of tocainide on theophylline elimination." Clin Pharmacol Ther, 51, p. 155
  2. Loi CM, Wei X, Parker BM, Korrapati MR, Vestal RE (1993) "The effect of tocainide on theophylline metabolism." Br J Clin Pharmacol, 35, p. 437-40

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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