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Drug Interactions between guaifenesin / oxtriphylline and ticlopidine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

ticlopidine oxtriphylline

Applies to: ticlopidine and guaifenesin / oxtriphylline

MONITOR: In one study, theophylline clearance was reduced by 37% and theophylline half-life increased by 42% during concomitant ticlopidine therapy. The exact mechanism of this interaction is not known, but ticlopidine probably interferes with theophylline metabolism.

MANAGEMENT: Theophylline levels and clinical response should be monitored when ticlopidine therapy is initiated or discontinued. Patients should be advised to report any signs of theophylline toxicity during concurrent therapy, including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physician.

References (1)
  1. Colli A, Buccino G, Cocciolo M, Parravicini R, Elli GM, Scaltrini G (1987) "Ticlopidine-theophylline interaction." Clin Pharmacol Ther, 41, p. 358-62

Drug and food interactions

Moderate

ticlopidine food

Applies to: ticlopidine

ADJUST DOSING INTERVAL: The bioavailability and gastrointestinal tolerance of ticlopidine is enhanced by food.

MANAGEMENT: Patients may be advised to take ticlopidine with meals.

References (1)
  1. (2001) "Product Information. Ticlid (ticlopidine)." Syntex Laboratories Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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