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Drug Interactions between guaifenesin / oxtriphylline and sulfinpyrazone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

sulfinpyrazone oxtriphylline

Applies to: sulfinpyrazone and guaifenesin / oxtriphylline

In one study, concomitant administration of sulfinpyrazone resulted in a 22% increase in total theophylline clearance. Changes noted in the elimination of theophylline included an increase in metabolism and a decrease in renal excretion. The clinical significance of this interaction is unknown. If sulfinpyrazone and theophylline are given together, clinical monitoring of patient response and serum theophylline levels is recommended. Patients should be advised to report worsening of their respiratory symptoms to their physician.

References (3)
  1. Upton RA (1991) "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet, 20, p. 135-50
  2. Birkett DJ, Miners JO, Attwood J (1983) "Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline-sulphinpyrazone interactions." Br J Clin Pharmacol, 15, p. 567-9
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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