Skip to main content

Drug Interactions between guaifenesin / oxtriphylline and lansoprazole

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Minor

oxtriphylline lansoprazole

Applies to: guaifenesin / oxtriphylline and lansoprazole

Lansoprazole may cause a minor decrease in the area under the plasma concentration-time curve of theophylline and related drugs. This effect appears to be small (approximately a 13% decrease in one study) and may be related either to a reduction in absorption or to enhanced clearance caused by induction of hepatic enzymes by lansoprazole. Dosage adjustment is not believed to be necessary. However, close observation for evidence of altered methylxanthine effect is recommended.

References (4)
  1. (2001) "Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc
  2. Granneman GR, Karol MD, Locke CS (1995) "Pharmacokinetic interaction between lansoprazole and theophylline." Ther Drug Monit, 17, p. 460-4
  3. Kokufu T, Ihara N, Sugioka N, Koyama H, Ohta T, Mori S, Nakajima K (1995) "Effects of lansoprazole on pharmacokinetics and metabolism of theophylline." Eur J Clin Pharmacol, 48, p. 391-5
  4. Ko JW, Jang IJ, Shin JG, Nam SK, Shin SG, Flockhart DA (1999) "Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers." Clin Pharmacol Ther, 65, p. 606-14

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer