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Drug Interactions between glycopyrrolate and methacholine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

glycopyrrolate methacholine

Applies to: glycopyrrolate and methacholine

ADJUST DOSING INTERVAL: Anticholinergics, beta-agonists, and theophylline may inhibit the bronchial airway response to methacholine. Methacholine is a cholinergic agonist that binds muscarinic receptors in bronchial smooth muscle, which leads to bronchoconstriction. Since patients with asthma exhibit greater sensitivity to induced bronchoconstriction than healthy subjects, methacholine is used to diagnose bronchial airway hyperreactivity in the absence of clinically apparent asthma. Bronchodilation caused by anticholinergics, beta-agonists, and theophylline may counteract methacholine-induced bronchoconstriction, possibly leading to diagnostic failure.

MANAGEMENT: Treatment with anticholinergics, beta-agonists, and theophylline should be interrupted before methacholine administration for the following durations:
--Short-acting anticholinergics (e.g., ipratropium): 12 hours
--Long-acting anticholinergics (e.g., tiotropium): At least 168 hours
--Short-acting beta-agonists (e.g., albuterol): 6 hours
--Long-acting beta-agonists (e.g., salmeterol): 36 hours (some authorities recommend 48 hours for ultra-long-acting beta-agonists [e.g., indacaterol, olodaterol, vilanterol])
--Oral theophylline: 12 to 48 hours

References (2)
  1. (2020) "Product Information. Provocholine (methacholine)." Galen Ltd
  2. (2022) "Product Information. Provocholine (methacholine)." Methapharm Inc, SUPPL-26

Drug and food interactions

Moderate

glycopyrrolate food

Applies to: glycopyrrolate

GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.

MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.

References (1)
  1. Linnoila M (1973) "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol, 6, p. 107-12

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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