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Drug Interactions between Glycerol and tigecycline

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

glycerin tigecycline

Applies to: Glycerol (glycerin) and tigecycline

MONITOR: The coadministration of diuretics with tetracyclines may result in decreased renal function and abnormalities in electrolytes and acid-base balance. As a class, tetracyclines can cause anti-anabolic effects which have led to increased blood urea nitrogen (BUN), azotemia, acidosis, and hyperphosphatemia. Diuretics have the potential to cause electrolyte and metabolic abnormalities, as well as worsen renal function. When used together, it is possible that these two classes of medications could have additive adverse effects.

MANAGEMENT: Patients on concomitant therapy with tetracycline antibiotics and diuretics should have their renal function and electrolytes monitored closely. The risk of additive adverse effects on the patient's renal function, electrolytes, and acid-base balance differs depending on the type of diuretic being used, the specific tetracycline antibiotic, and the clinical status of the patient. The manufacturer's labeling should be consulted for more specific recommendations.

References

  1. Jick H, Slone D, Shapiro S, et al. (1972) "Tetracycline and drug-attributed rises in blood urea nitrogen: a report from the Boston Collaborative Drug Surveillance Program." JAMA, 220, p. 377-9
  2. Garty M, Hurwitz A (1980) "Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline." Clin Pharmacol Ther, 28, p. 203-7
  3. Tannenberg AM (1972) "Tetracycline and rises in urea nitrogen." JAMA, 221, p. 713
  4. Alexander MR (1972) "Tetracycline and rises in urea nitrogen." JAMA, 221, p. 713-4
  5. (2022) "Product Information. Xerava (eravacycline)." PAION Deutschland GmbH
  6. (2021) "Product Information. Xerava (eravacycline)." Tetraphase Pharmaceuticals, Inc
  7. (2022) "Product Information. Ospolot (sulthiame)." Phebra Pty Ltd, 10
  8. (2022) "Product Information. AcetaZOLAMIDE (acetaZOLAMIDE)." Mylan Institutional (formerly UDL Laboratories)
  9. (2021) "Product Information. AMILoride Hydrochloride (aMILoride)." Padagis
  10. (2020) "Product Information. Spironolactone (spironolactone)." Amneal Pharmaceuticals
  11. (2022) "Product Information. Kerendia (finerenone)." Bayer Pharmaceutical Inc
  12. (2021) "Product Information. Eplerenone (eplerenone)." Westminster Pharmaceuticals LLC
View all 12 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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