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Drug Interactions between glycerol phenylbutyrate and Xenical

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

orlistat glycerol phenylbutyrate

Applies to: Xenical (orlistat) and glycerol phenylbutyrate

MONITOR: Concomitant use of glycerol phenylbutyrate with medicines known to inhibit pancreatic lipases may theoretically lead to reduced intestinal absorption of its active moiety phenylbutyrate, and hence reduced control of plasma ammonia levels. After oral ingestion, pancreatic lipases hydrolyse glycerol phenylbutyrate in the small intestine to glycerol and phenylbutyrate, allowing the absorption of phenylbutyrate and its subsequent conversion to the active metabolite, phenylacetic acid, by beta-oxidation. Clinical data are not available.

MANAGEMENT: Caution and close monitoring of ammonia levels is recommended if glycerol phenylbutyrate is to be administered with a gastrointestinal lipase inhibitor such as orlistat. The dose of glycerol phenylbutyrate should be adjusted as necessary per local guidelines.

References (2)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. (2013) "Product Information. Ravicti (glycerol phenylbutyrate)." Hyperion Therapeutics Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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