Drug Interactions between glycerol phenylbutyrate and sodium phenylbutyrate
This report displays the potential drug interactions for the following 2 drugs:
- glycerol phenylbutyrate
- sodium phenylbutyrate
Interactions between your drugs
No interactions were found between glycerol phenylbutyrate and sodium phenylbutyrate. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
glycerol phenylbutyrate
A total of 263 drugs are known to interact with glycerol phenylbutyrate.
- Glycerol phenylbutyrate is in the drug class urea cycle disorder agents.
- Glycerol phenylbutyrate is used to treat Urea Cycle Disorders.
sodium phenylbutyrate
A total of 31 drugs are known to interact with sodium phenylbutyrate.
- Sodium phenylbutyrate is in the drug class urea cycle disorder agents.
- Sodium phenylbutyrate is used to treat Urea Cycle Disorders.
Drug and food interactions
sodium phenylbutyrate food
Applies to: sodium phenylbutyrate
ADJUST DOSING INTERVAL: Coadministration with a high-fat meal may reduce the rate and extent of absorption of sodium phenylbutyrate. When a single 3 g-1 g dose of sodium phenylbutyrate-taurursodiol (sodium phenylbutyrate-ursodoxicoltaurine) was administered to healthy volunteers in the presence of a high-fat, high-calorie meal (approximately 800 to 1000 calories; 500 to 600 calories from fat, 250 calories from carbohydrate, 150 calories from protein), sodium phenylbutyrate peak plasma concentration (Cmax) decreased by 75% and systemic exposure (AUC) decreased by 55%. The Cmax for taurursodiol was not significantly affected, but AUC was increased by 46%. The clinical significance of these changes has not been established. In premarketing studies, patients were advised to take the drug before a meal.
MANAGEMENT: The prescribing information recommends administration of sodium phenylbutyrate-taurursodiol before a meal or snack, particularly in patients of low body weight (less than 70 kg).
References
- (2022) "Product Information. Relyvrio (sodium phenylbutyrate-taurursodiol)." Amylyx Pharmaceuticals, 1
- (2022) "Product Information. Albrioza (sodium phenylbutyrate-ursodoxicoltaurine)." Innomar Strategies Inc.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Urea cycle disorder agents
Therapeutic duplication
The recommended maximum number of medicines in the 'urea cycle disorder agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'urea cycle disorder agents' category:
- glycerol phenylbutyrate
- sodium phenylbutyrate
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.