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Drug Interactions between glucagon and OptiPranolol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

metipranolol ophthalmic glucagon

Applies to: OptiPranolol (metipranolol ophthalmic) and glucagon

Beta-blockers may blunt the hyperglycemic reaction to glucagon by interfering with beta-adrenergic-mediated hyperglycemic counter-regulatory mechanisms. In addition, glucagon may diminish the bradycardic effect of beta-blockers by inducing a transient increase in pulse and blood pressure. Patients with coronary artery disease may require treatment for the potential increase in blood pressure and heart rate.

References

  1. Pun KK, Yeung CK, Chak W, et al. "Effects of selective and non-selective beta-blockers on the alanine and free fatty acid responses to glucagon challenge in hemodialysis patients." Clin Nephrol 26 (1986): 222-6
  2. Messerli FH, Kuchel O, Tolis G, Hamet P, Fraysse J, Genest J "Effects of B-adrenergic blockade on plasma cyclic AMP and blood sugar responses to glucagon and isoproterenol in man." Int J Clin Pharmacol 14 (1976): 189-94
  3. Smith RC, Wilkinson DO, Hull RL "Glucagon for propranolol overdose." JAMA 254 (1985): 2412
  4. Mills GA, Horn JR "B-blockers and glucose control." Drug Intell Clin Pharm 19 (1985): 246-51
  5. Smith RC, Wilkinson J, Hull RL "Glucagon for propranolol overdose." JAMA 254 (1985): 2412
  6. "Product Information. Glucagon (glucagon)." Lilly, Eli and Company PROD (2001):
  7. "Product Information. GlucaGen (glucagon)." Novo Nordisk Pharmaceuticals Inc PROD (2001):
  8. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  9. Cerner Multum, Inc. "Australian Product Information." O 0
  10. "Product Information. Baqsimi (glucagon)." Lilly, Eli and Company (2019):
  11. "Product Information. Zegalogue Prefilled Syringe (dasiglucagon)." Zealand Pharma A/S (2021):
View all 11 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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