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Drug Interactions between Gleevec and meloxicam

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

meloxicam imatinib

Applies to: meloxicam and Gleevec (imatinib)

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with CYP450 2C9 inhibitors may increase the plasma concentrations of meloxicam. The proposed mechanism is inhibition of the CYP450 2C9-mediated metabolism of meloxicam, which has been shown in vitro to be primarily metabolized by this isoenzyme, and, to a lesser extent, by CYP450 3A4. In a study involving healthy volunteers, voriconazole (a weak CYP450 2C9 inhibitor) increased meloxicam's systemic exposure by 47% and extended its average half-life by 51%. Patients who are known or suspected poor CYP450 2C9 metabolizers may be at increased risk for elevated plasma levels due to decreased metabolic clearance of meloxicam. Clinical data on the use of meloxicam with other, more potent CYP450 2C9 inhibitors are lacking.

MANAGEMENT: The potential for an interaction should be considered during concomitant use. Some manufacturers advise against their combined use. If coadministration is required, monitor patients for NSAID-related side effects and toxicity, including gastrointestinal bleeding or perforation. Dose adjustment of meloxicam may be warranted. Refer to the prescribing information for each medication for additional guidance.

Drug and food/lifestyle interactions

Moderate

imatinib food/lifestyle

Applies to: Gleevec (imatinib)

Grapefruit juice may increase the blood levels of certain medications such as imatinib. You should avoid consumption of grapefruit and grapefruit juice during treatment with imatinib. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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