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Drug Interactions between glecaprevir / pibrentasvir and selinexor

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

glecaprevir selinexor

Applies to: glecaprevir / pibrentasvir and selinexor

MONITOR: Coadministration with selinexor may increase the plasma concentrations of drugs that are substrates of the organic anion transporting polypeptide (OATP) 1B3. The proposed mechanism, based on in vitro studies, is decreased clearance due to inhibition of OATP1B3 by selinexor. The clinical relevance of this interaction is unknown.

MANAGEMENT: Caution is advised if selinexor is used concomitantly with drugs that are substrates of OATP1B3, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever selinexor is added to or withdrawn from therapy.

References (1)
  1. (2022) "Product Information. Xpovio (selinexor)." Antengene (Aus) Pty Ltd, Version 1.0- 08 Marc

Drug and food interactions

Moderate

glecaprevir food

Applies to: glecaprevir / pibrentasvir

ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of glecaprevir and pibrentasvir. Relative to fasting conditions, mean glecaprevir systemic exposure (AUC) increased by 83% to 163% and mean pibrentasvir AUC increased by 40% to 53% when administered with moderate to high fat meals.

MANAGEMENT: Glecaprevir-pibrentasvir should be administered with food.

References (1)
  1. (2017) "Product Information. Mavyret (glecaprevir-pibrentasvir)." Abbott Pharmaceutical

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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