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Drug Interactions between Gattex and Natpara

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between Gattex and Natpara. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Gattex

A total of 16 drugs are known to interact with Gattex.

Natpara

A total of 5 drugs are known to interact with Natpara.

Drug and food interactions

Moderate

teduglutide food

Applies to: Gattex (teduglutide)

MONITOR: Teduglutide has the potential to increase absorption of concomitantly administered oral medications. Altered mental status in association with teduglutide treatment has been observed in patients on benzodiazepines in clinical trials. In one case, a patient who received prazepam with teduglutide 0.05 mg/kg/day experienced dramatic deterioration in mental status progressing to coma during her first week of teduglutide therapy. She was admitted to the intensive care unit, where her benzodiazepine level was found to exceed 300 mcg/L. Both medications were discontinued, and the coma resolved five days later.

MANAGEMENT: Careful monitoring and possible dosage adjustment of oral medications that require titration or have a narrow therapeutic index are recommended during coadministration with teduglutide.

References

  1. (2013) "Product Information. Gattex (teduglutide)." NPS Pharmaceuticals

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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