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Drug Interactions between Garlix and metyrosine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

metyroSINE garlic

Applies to: metyrosine and Garlix (garlic)

Garlic has been found in some studies to lower blood pressure and may theoretically potentiate the effects of hypotensive agents. A meta-analysis of 11 randomized, placebo-controlled studies showed a mean decrease of 4.6 mmHg for systolic blood pressure and no significant effect for diastolic blood pressure in subjects treated with garlic (most often garlic powder 600 to 900 mg/day, providing 3.6 to 5.4 mg of the active component allicin) compared to placebo. In the subgroup analysis of studies where subjects had a mean baseline blood pressure in the hypertensive range (SBP 140 mmHg or higher; DBP 90 mmHg or higher), mean decrease associated with garlic was 8.4 mmHg and 7.3 mmHg, respectively, for systolic and diastolic blood pressure. There have been no reports of clinical hypotension associated with concomitant use of garlic and antihypertensive agents.

References (2)
  1. Richard CL, Jurgens TM (2005) "Effects of natural health products on blood pressure." Ann Pharmacother, 39, p. 712-20
  2. Tattelman E (2005) "Health effects of garlic." Am Fam Physician, 72, p. 103-6

Drug and food interactions

Moderate

metyroSINE food

Applies to: metyrosine

MONITOR: Metyrosine, when coadministered with other CNS depressants including alcoholic beverages, may lead to excessive somnolence and other forms of nervous system depression.

MANAGEMENT: The patient should be informed to use caution if these agents are coadministered, especially if performing hazardous tasks such as driving or operating machinery.

References (1)
  1. (2001) "Product Information. Demser (metyrosine)." Merck & Co., Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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