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Drug Interactions between ganaxolone and pemoline

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

pemoline ganaxolone

Applies to: pemoline and ganaxolone

MONITOR: Decreased seizure threshold has been reported in patients receiving pemoline concomitantly with antiepileptic medications. The mechanism of interaction has not been described, although convulsive seizures have been reported as a side effect of pemoline.

MANAGEMENT: Caution and clinical monitoring are advised when pemoline is used in patients receiving anticonvulsant therapy. Patients should be advised to notify their physician if they experience loss of seizure control.

References (1)
  1. (2001) "Product Information. Cylert (pemoline)." Abbott Pharmaceutical

Drug and food interactions

Moderate

ganaxolone food

Applies to: ganaxolone

ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of ganaxolone. When administered with a high-fat meal, ganaxolone peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 3- and 2-fold, respectively, compared to administration under fasted conditions. Ganaxolone was administered with food in the premarketing study population. The efficacy of ganaxolone when administered in the fasted state is unknown.

GENERALLY AVOID: Concomitant use of ganaxolone with central nervous system (CNS) depressants, including alcohol, may potentiate adverse effects such as somnolence and sedation.

MANAGEMENT: Ganaxolone must be administered with food according to the manufacturer. Patients should be advised to avoid or limit consumption of alcohol and to avoid activities requiring mental alertness such as driving or operating hazardous machinery until they know how the medication affects them.

References (1)
  1. (2022) "Product Information. Ztalmy (ganaxolone)." Marinus Pharmaceuticals, Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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