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Drug Interactions between gallium Ga 68 gozetotide and Nubeqa

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

darolutamide gozetotide

Applies to: Nubeqa (darolutamide) and gallium Ga 68 gozetotide

MONITOR: The concomitant use of antiandrogens or androgen deprivation therapy may affect the uptake of gallium Ga-68 PSMA-11, also known as gallium Ga-68 gozetotide, and diminish its diagnostic effects in patients with prostate cancer. However, the clinical impact of these drugs on the performance of gallium Ga-68 PSMA-11 has not been established.

MANAGEMENT: Clinicians should be aware of possible interference with diagnostic tests in patients who are taking these medications.

References (2)
  1. (2022) "Product Information. Ga 68 PSMA-11 (gallium Ga-68 PSMA-11)." UCLA Biomedical Cyclotron Facility
  2. (2022) "Product Information. Locametz (gozetotide)." Advanced Accelerator Applications

Drug and food interactions

Moderate

darolutamide food

Applies to: Nubeqa (darolutamide)

ADJUST DOSING INTERVAL: Food enhances the oral absorption of darolutamide. According to the prescribing information, bioavailability of darolutamide increased by 2.0 to 2.5-fold when administered with food. A similar increase in exposure was observed for the active metabolite keto-darolutamide.

MANAGEMENT: Darolutamide should be administered with food.

References (1)
  1. (2019) "Product Information. Nubeqa (darolutamide)." Bayer HealthCare Pharmaceuticals Inc.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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